49ers vs Panthers Opening Odds, Betting Lines & Prediction for Week 5 Game on FanDuel Sportsbook

Week 4 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 5, giving us an early preview of next week's slate.

Week 5's late slate sets up an exciting NFC matchup between the San Francisco 49ers and Carolina Panthers.

49ers vs Panthers Odds & Lines Week 5

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-178) | CAR: (+150)
Spread: SF: -3.5 (-105) | CAR: +3.5 (-115)
Total: N/A — Over: (N/A) | Under: (N/A)

The 49ers are poised for a close game on the road in Week 5 against the Panthers. San Francisco is an early -178 moneyline favorite and is favored by 3.5 points on the spread.

49ers vs Panthers Prediction Week 5

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
49ers: 44.7% to win
Panthers: 54.7% to win

This battle could be determined within the final few possessions, according to the opening betting lines. ESPN's FPI seems to think the Panthers will emerge victorious and I believe they will at least be able to keep the score close. Carolina's woeful offense has forced people to overlook how dominant their defense has been. Young stars like Jeremy Chinn and experienced pros like Brian Burns are getting the job done. The 49ers have only scored 20 total points across two away games, so bet Panthers +3.5 (-115).

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.