NFL - Odds & Predictions

49ers vs Panthers Expert Picks & Predictions for Week 5 NFL Game

Devon Platana
49ers vs. Panthers expert picks, predictions and projections for NFL Week 5 game.
49ers vs. Panthers expert picks, predictions and projections for NFL Week 5 game. / AP Photos/Matt Patterson

The 2022 NFL season is underway and the Week 5 schedule is full of exciting showdowns. One of the more interesting matchups is an NFC clash between the San Francisco 49ers and Carolina Panthers.

The 49ers are riding a high this week after their huge 24-9 victory over the Los Angeles Rams on Monday Night Football. On the other hand, the Baker Mayfield era has been a disaster for the Panthers, who dropped to 1-3 following a 26-16 loss to the Arizona Cardinals.

Can San Francisco continue showcasing their ability to be Super Bowl contenders this year? Or does Carolina have what it takes to pull off a major upset at home?

Here's what projection models and experts across the industry have to say about the 49ers vs Panthers Week 5 matchup.

49ers vs Panthers Projections

ESPN FPI49ers (50.9%)
numberFire49ers (63.7%)
FiveThirtyEight49ers (70%)
Betting Favorite49ers (-6.5)

Projected Winner: 49ers (4)

49ers vs Panthers Expert Picks

ESPN Experts: 49ers (7)
Sports Illustrated Experts49ers (5)
CBS Sports Experts49ers (7)

Expert Totals: 49ers (19)

When it comes to projections, the four highlighted sources are all backing the 49ers to win. The 19 highlighted experts are also on the same page, unanimously backing San Francisco as well.

There's really no need to overthink this one. The 49ers are the clear-cut better team and shouldn't have any issues with the Panthers, barring a total collapse.

dark. SIGN UP NOW. No Sweat First Bet Up To $1,000

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.