49ers vs Broncos Prediction, Odds & Betting Trends for NFL Week 3 Sunday Night Football on FanDuel Sportsbook

49ers vs Broncos Week 3 Game Info

2022 NFL Regular Season Game
San Francisco 49ers (1-1, 0-1 Away) vs. Denver Broncos (1-1, 1-0 Home)
Date: Sunday, Sept. 25, 2022
Time: 8:20 p.m. ET
Venue: Empower Field at Mile High — Denver, CO
Coverage: NBC

Week 3 of the 2022 NFL season includes a Sunday Night Football showdown between the San Francisco 49ers and Denver Broncos. After a disappointing loss to open the year, the 49ers bounced back with a 27-7 win against the Seattle Seahawks. Unfortunately, it wasn't all good news as San Francisco lost starting quarterback Trey Lance to a broken ankle for the rest of the season.

The Broncos also got their first win of the year by defeating the Houston Texans, 16-9, on Sunday. It was far from the most exciting game for Denver, however, wideout Courtland Sutton did impress by pacing his team in targets (11), receptions (7) and receiving yards (122).

49ers vs Broncos Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-110) | DEN: (-106)
Spread: SF: -1 (-106) | DEN: +1 (-114)
Total: 45.5 —Over: (-105) | Under: (-115)

Updated (Sunday, Sept. 25, 12:30 p.m. ET): Odds for this game remain relatively unchanged since opening. The biggest movement is the Broncos going from -102 to -106 on the moneyline, while the 49ers fell from -116 to -110.

The 49ers enter this contest as the favorite on the moneyline and spread on FanDuel Sportsbook's NFL odds. This 8:20 p.m. ET game also features a total of 38.5, which is fairly average compared to the rest of the Week 3 slate.

49ers vs Broncos Prediction & Pick

Russell Wilson is no stranger to facing the 49ers, having played them 20 times as a member of the Seahawks. While he's won a whopping 16 of those matchups, things are a bit different now that he's playing with a Broncos offense playing below expectations, averaging 16.0 points per game (No. 26).

It isn't like the Broncos have even played any world-class defenses yet. Meanwhile, San Francisco just put up 27 points against the same Seattle defense that held Denver to 16 in Week 1. With the 49ers seemingly playing more confident with Jimmy Garoppolo under center as well, I could see San Francisco grabbing the road win here.

Final Score Prediction: 49ers: 28 | Broncos: 20

49ers vs Broncos Betting Trends

- San Francisco is 10-4 straight up in its last 14 games.
- Denver is 1-5 against the spread (ATS) in its last six games.
- The total has hit the under in six of San Francisco's last seven road games.
- The total has hit the under in four of Denver's last six games against San Francisco.

49ers vs Broncos Best Bet

As proven by the odds, this is a game that could go either way. While the Broncos were pegged as Super Bowl contenders, their offense hasn't come close to living up to its potential. I expect that the 49ers will be a more confident team with Garoppolo under center and with the spread situation being a pick'em, I'll take San Francisco as the 1-point favorite at -110 odds.

Bet: 49ers -1 (-110)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.