NFL - Odds & Predictions

3 Best Prop Bets for 49ers vs Cardinals Monday Night Football Week 11 (George Kittle Torches a Division Rival)

Larry Rupp
Best prop bets for San Francisco 49ers vs Arizona Cardinals Monday Night Football Week 11 game.
Best prop bets for San Francisco 49ers vs Arizona Cardinals Monday Night Football Week 11 game. / AP Photos/Scot Tucker
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Week 11 of the 2022 NFL season wraps up with a Monday Night Football battle between the San Francisco 49ers and Arizona Cardinals. The 49ers will aim to move into a tie for first place in the NFC West, while the Cardinals will look to win back-to-back games with quarterback Colt McCoy.

Here are three of the best prop bets for the 49ers vs Cardinals matchup, courtesy of NFL odds on FanDuel Sportsbook.

49ers vs Cardinals MNF Prop Bets Tonight

1. George Kittle - Receiving Yards: Over 47.5 (-110)

The Cardinals simply cannot stop opposing tight ends from balling out this season. Arizona is allowing an average of 77.8 yards on 7.5 receptions per game to the position. Both of those marks rank as the highest in the NFL. That bodes well for George Kittle and his chances of being used more as a receiver than a blocker tonight. Kittle averages a reliable 64.8 yards per game against Arizona in his career and has posted at least 48 yards in each of his last six games against the Cardinals. He is also averaging 11.7 yards per reception on the year, meaning he may only need 4 receptions to reach cash this prop. Kittle has logged 4 receptions in four of his seven games.

2. James Conner - Receiving Yards: Under 19.5 (-110)

James Conner has returned to his workhorse role on head coach Kliff Kingsbury's offense. He saw a season-high 24 touches in Week 11 and played in 96% of the offensive snaps. However, he still failed to rack up at least 20 receiving yards for the fourth time in his last five games. Conner has never been known as much of a threat in the passing attack and now faces a 49ers defense that has allowed the ninth-fewest receiving yards to opposing RBs (295). With Nick Bosa and Samson Ebukam staring McCoy down on the defensive line, look for Conner to be tasked with helping in pass protection and not leaking out as a dump-off option.

3. Anytime Touchdown Scorer: Brandon Aiyuk (+175)

It's easy to forget about wide receiver Brandon Aiyuk in an offense that features the likes of Kittle, Deebo Samuel and Christian McCaffrey. One person that has't forgotten about him, especially near the end zone, is quarterback Jimmy Garoppolo. Aiyuk has seen at least 1 red zone target in six of San Francisco's nine games and is already only one touchdown away from tying his career-high mark of 5 scores. Arizona presents as a positive matchup considering the Cardinals are tied for the fifth-most passing touchdowns allowed in the NFL (17). Stacking the box against a powerful San Francisco backfield will leave Arizona susceptible to guys like Aiyuk in one-on-one coverage. The former Arizona State standout has sneaky value here.

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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