Patriots vs Browns Opening Odds, Betting Lines & Prediction for Week 6 Game on FanDuel Sportsbook

Updated: Sep 10, 5:00pm UTC

Week 5 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 6, giving us an early preview of next week's slate.

Week 6's 1 p.m. slate sets up an exciting AFC matchup between the New England Patriots and Cleveland Browns.

Patriots vs Browns Odds & Lines Week 6

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NE: (+160) | CLE: (-190)
Spread: NE: +3.5 (-110) | CLE: -3.5 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

The Browns are tabbed as small favorites when they welcome the Patriots to town in Week 6. Cleveland is an early -190 moneyline favorite and is favored by 3.5 points on the spread.

Patriots vs Browns Prediction Week 6

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
Patriots: 26.3% to win
Browns: 73.5% to win

The Patriots are likely going to find themselves as underdogs for most of their matchups until starting quarterback Mac Jones returns from an ankle injury, which could potentially be in Week 6. Still, ESPN's FPI gives New England only a 26.3% chance of pulling off the upset and even that mark may be generous.

Cleveland ranks among the top 10 NFL teams in offensive DVOA rating and New England ranks outside the top 20 NFL teams in defensive DVOA rating. The Browns also have one of the best RB duos in the NFL in Nick Chubb and Kareem Hunt. Those two should run wild here, so bet Cleveland -3.5 (-110).

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.