Ohio State vs Michigan State Prediction, Odds & Betting Trends for College Football Game on FanDuel Sportsbook

Ohio State vs Michigan State Week 6 Game Info

2022 NCAA College Football Game
No. 3 Ohio State Buckeyes (5-0, 2-0 Big Ten) vs. Michigan State Spartans (2-3, 0-2 Big Ten)
Date: Saturday, Oct. 8, 2022
Time: 4 p.m. ET
Venue: Spartan Stadium — East Lansing, MI
Coverage: ABC

Week 6 of the 2022 NCAA college football season includes a Big Ten battle between the No. 3 Ohio State Buckeyes and Michigan State Spartans. The Buckeyes have played five straight home games to start the season, and buried their first two Big Ten opponents. Last week it was Rutgers 49-10, and the week prior Wisconsin, 52-21.

Meanwhile, Michigan State has been a major disappointment this season. With three straight losses by double-digits to Washington, Minnesota and Maryland entering this contest, it looks like the Spartans could be another Buckeyes blowout victim.

Ohio State vs Michigan State Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: OSU: (-4000) | MSU: (+1400)
Spread: OSU: -26.5 (-115) | MSU: +26.5 (-105)
Total: 64.5 — Over: (-115) | Under: (-105)

Ohio State is a monster -26.5 road favorite on the spread, and -4000 on the moneyline. The takeback on underdog Michigan State is +1400, or 14/1 odds and return on your bet on a Spartans stunning victory. The total is higher at 64.5 points, which is more than a touchdown higher than an average college football total.

Ohio State vs Michigan State Prediction & Pick

The Buckeyes are 7-1 ATS against Michigan State in their last eight trips to East Lansing. Ohio State projects to pile up near 500 yards offense with leading Heisman favorite QB CJ Stroud already at 1,376 passing yards and 18 TD passes. He'll face a Spartans secondary that has been abysmal the last three games.

The Buckeyes run for 226 yards and pass for 303 yards per game. Ohio State's 529 yards per game offense ranks No. 3 in the country. Stroud and the Buckeye's offense should shred a Spartans pass defense that is allowing 275 passing yards per game and ranks second-to-last in pass defense efficiency while getting just one sack in the last three games.

Final Score Prediction: Ohio State: 41 | Michigan State: 17

Ohio State vs Michigan State Betting Trends

- Ohio State is 6-0 straight up (SU) in their last 6 games.
- Ohio State is 13-1 SU in their last 14 road games.
- Ohio State is 5-0 against the spread (ATS) in their last 5 games vs Michigan State.
- The total has gone Over in 5 of Ohio State's last 7 games.
- Michigan State is 8-1 SU in their last 9 home games.
- The total has gone Under in 5 of Michigan State's last 6 games.

Ohio State vs Michigan State Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

ESPN's Football Power Index gives the Buckeyes an 88.6% chance to win based on the huge point spread. Last year, Michigan State was 9-1 when they traveled to Columbus, and the Spartans were blown out 56-7. A blowout seems likely again, but the Spartans would have been closer to a +14 to +16 point underdog if this game were played in Week 2.

With dichotomous results since then for both teams, the huge home underdog offers some value with an opportunity to rise up and play better against the powerful Buckeyes. Contrary call on the Spartans.

Bet: Michigan State +26.5 (-105)

Game odds refresh periodically and are subject to change.