NFL - Odds & Predictions

Jaguars vs Colts Prediction, Odds & Betting Trends for NFL Week 6 Game on FanDuel Sportsbook (Oct 16)

Larry Rupp
Jacksonville Jaguars vs Indianapolis Colts prediction, odds and betting trends for NFL Week 6 game.
Jacksonville Jaguars vs Indianapolis Colts prediction, odds and betting trends for NFL Week 6 game. / AP Photos/Matt Patterson

Jaguars vs Colts Week 6 Game Info

2022 NFL Regular Season — Week 6
Jacksonville Jaguars (2-3, 1-2 Away) vs. Indianapolis Colts (2-2-1, 1-1 Home)
Date: Sunday, October 16, 2022
Time: 1:00 p.m. ET
Venue: Lucas Oil Stadium — Indianapolis, IN
Coverage: CBS

Two teams vying for the AFC South title meet head-to-head in the Week 6 as the Indianapolis Colts host the Jacksonville Jaguars. The Jaguars struggled to finish off a number of promising drives in Week 5 and it led to just a pair of field goals. The Houston Texans were able to come out on top, 13-6.

Meanwhile, the Colts got back to the .500 mark with an overtime win against the Denver Broncos in Week 5. Cornerback Stephon Gilmore's pass breakup in the end zone on a fourth down try sealed the win for Indianapolis. Four field goals by kicker Chase McLaughlin led the way in a 12-9 final score.

Jaguars vs Colts Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: JAC: (+110) | IND: (-130)
Spread: JAC: +2.5 (-114) | IND: -2.5 (-106)
Total: 41.5 — Over: (-110) | Under: (-110)

The Colts enter this contest as a small home favorite on the moneyline and the spread. This 1:00 p.m. ET clash also features one of the lower totals on the Week 6 slate at 41.5 points.

Jaguars vs Colts Prediction & Pick

There's a good chance this game has a major impact on the final AFC South standings for the 2022 NFL season. Divisional matchups are crucial to win for tiebreaker scenarios. This one is a toss-up, so I'll roll with the better starting quarterback here. That is certainly not the struggling Matt Ryan.

Ryan leads the league in interceptions (7) as well as fumbles (11) and has been sacked an NFL-high 21 times already. Turnovers are going to be they key to this game and the Jaguars are tied for fifth in the NFL with 9 takeaways on the year. That gives them a major edge in what should be a close one.

Final Score Prediction: Jaguars: 20 | Colts: 17

Jaguars vs Colts Betting Trends

- Jacksonville is 4-2 straight up in its last six games against Indianapolis.
- The total has hit the over in six of Jacksonville's last nine games.
- Indianapolis is 2-5 against the spread (ATS) in its last seven games.
- The total has hit the under in four of Indianapolis' last five games against Jacksonville.

Jaguars vs Colts Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

Jacksonville is 4-2 straight up in its last six games against Indianapolis and has covered the spread in every single one of those six contests. Not only that, but the Colts are also 1-6 against the spread (ATS) in their last seven games against an AFC South opponent. The Jaguars should be favored here.

The health of starting running back Jonathan Taylor is another part of this matchup to keep an eye on. He was sidelined in Week 5 with an ankle issue and may not be 100% healthy heading into Sunday. If he is limited in any way, the Jaguars have a much better chance of balling out on defense.

Bet: Jacksonville Jaguars ML (+110)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.