Chargers vs 49ers Prediction, Odds & Best Bet for Sunday Night Football (Prepare for Bay Area Shootout)

Chargers vs 49ers Week 10 Game Info

2022 NFL Regular Season Game
Los Angeles Chargers (5-3, 3-1 Away) vs. San Francisco 49ers (4-4, 2-1 Home)
Date: Sunday, Nov. 13, 2022
Time: 8:20 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: NBC

Week 10 of the 2022 NFL season includes a clash between California-based teams as the Los Angeles Chargers are slated to pay a visit to the San Francisco 49ers. The Chargers have been one of the NFL's hotter teams lately, winning four of their last five games — including last week's 20-17 win over the Atlanta Falcons.

After back-to-back losses, the 49ers returned to their winning ways with a 31-14 victory against the LA Rams back in Week 9. Superstar running back Christian McCaffrey had a terrific game, tallying 149 total yards from scrimmage with two touchdowns on 26 touches, even throwing a 34-yard passing TD to Brandon Aiyuk.

Chargers vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LAC: (+245) | SF: (-300)
Spread: LAC: +7 (-114) | SF: -7 (-106)
Total: 45.5 —Over: (-108) | Under: (-112)

The 49ers enter this contest as clear favorites on the moneyline and spread on FanDuel Sportsbook's updated odds. This inter-conference clash also features an over/under of 45.5, which is tied for the fourth-highest Week 10 total.

Chargers vs 49ers Prediction & Pick

The 49ers have the benefit of entering this game well-rested after last week's bye. The run-heavy team must now take advantage of a Chargers defense that surrenders 159.5 rushing yards per road game, which is the third-worst clip in the league.

With the 49ers being at home, I expect them to hand the ball to McCaffrey early and often. He's averaging a solid 5.2 rushing yards per carry over his last three games, after all. Besides, fellow RB Elijah Mitchell has been activated from the injured reserve, giving San Francisco yet another dangerous weapon.

It'll also be hard for the Chargers to succeed without their top two wideouts. Mike Williams has already been ruled out with an ankle injury while Keenan Allen has yet to practice this week after he was sidelined in Week 9 with a hamstring issue. As good as quarterback Justin Herbert and RB Austin Ekeler are, they can't get it done on their own.

Back the 49ers taking advantage of the Chargers' awful run defense, leading to a home victory.

Final Score Prediction: 49ers: 31 | Chargers: 24

Chargers vs 49ers Betting Trends

- The Chargers are 5-0 straight up in their last five games against San Francisco.
- San Francisco is 6-1 against the spread (ATS) in its last seven home games.
- The total has hit the over in seven of the Chargers' last 10 games against the NFC West.
- The total has hit the over in eight of San Francisco's last 11 games against the Chargers.

Chargers vs 49ers Best Bet

On paper, neither team's overall offensive numbers are eye-popping this season. However, it's worth noting that the 49ers have the 10th-best home offense (24.7 PPG) this season, whereas the Chargers are tied for having the fifth-best road offense (27.0 PPG).

With the total also going over in eight of the last 11 Chargers-49ers matchups, I can see the presence of players like McCaffrey, Cooper Kupp and Deebo Samuel leading to the over being hit yet again.

Bet: Over 45.5 Points (-108)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.