NFL - Odds & Predictions

49ers vs Falcons Prediction, Odds & Betting Trends for NFL Week 6 Game on FanDuel Sportsbook (Oct 16)

Larry Rupp
San Francisco 49ers vs Atlanta Falcons prediction, odds and betting trends for NFL Week 6 game.
San Francisco 49ers vs Atlanta Falcons prediction, odds and betting trends for NFL Week 6 game. / AP Photos/Chris O'Meara
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49ers vs Falcons Week 6 Game Info

2022 NFL Regular Season — Week 6
San Francisco 49ers (3-2, 1-2 Away) vs. Atlanta Falcons (2-3, 1-1 Home)
Date: Sunday, October 16, 2022
Time: 1:00 p.m. ET
Venue: Mercedes-Benz Stadium — Atlanta, GA
Coverage: FOX

The San Francisco 49ers will look to extend their winning streak to three games when they visit the Atlanta Falcons in Week 6 of the 2022 NFL season. Running back Jeff Wilson's big day (18 touches, 132 yards, 1 touchdown) guided the 49ers to a 37-15 road win over the Carolina Panthers on Sunday.

Meanwhile, the Falcons fell just short of an upset win over the Tampa Bay Buccaneers in Week 5. Atlanta was down 21-0 entering the fourth quarter before they scored 2 touchdowns to make it a one-possession game. Tampa Bay was eventually able to run out the clock and secure a 21-15 win.

49ers vs Falcons Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-240) | ATL: (+198)
Spread: SF: -5.5 (-110) | ATL: +5.5 (-110)
Total: 42.5 — Over: (-110) | Under: (-110)

The 49ers enter this contest as a clear road favorite on the moneyline and the spread. This 1:00 p.m. ET clash also features one of the lower totals on the Week 6 slate at 42.5 points.

49ers vs Falcons Prediction & Pick

The Falcons are an undeniably feisty team. Each of their five games have been decided by six points or fewer and each one came down to the final minutes of the fourth quarter. Atlanta has the talent to pull off an upset in any given week, but seeing the 49ers lose this one would be a surprising outcome.

San Francisco has the edge here because of its defense. The 49ers are allowing a league-best 249.2 yards per game as well as a league-best 4.0 yards per play. Quarterback Marcus Mariota is going to be running for his life and trying to fit the ball in the tightest of spaces, which is never a good thing.

Final Score Prediction: 49ers: 27 | Falcons: 17

49ers vs Falcons Betting Trends

- San Francisco is 4-2 straight up in its last six games against Atlanta.
- The total has hit the under in five of San Francisco's last six away games.
- Atlanta is 5-0 against the spread (ATS) in its five games played this season.
- The total has hit the over in four of Atlanta's last six games against San Francisco.

49ers vs Falcons Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

It's not hard to understand that the 49ers score more points in their wins than they do in their losses. San Francisco is averaging a reliable 29.3 points per game across their three victories on the year, but is averaging 10.0 points per game across their two losses. That has an impact on this point total.

The 49ers are expected to win this one and it wouldn't be shocking to see them put up 27 or more points against a Falcons defense that is allowing 24.4 points per game (T-No. 21 in NFL). That means Atlanta would only need to score around 17 points to hit the over, which is a mark it has hit in four of five games.

Bet: Over 42.5 Points (-110)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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