Wyoming vs BYU Prediction, Odds & Betting Trends for College Football Week 4 Game on FanDuel Sportsbook

Wyoming vs BYU Week 4 Game Info

2022 NCAA College Football Game
Wyoming Cowboys (3-1) vs. No. 19 BYU Cougars (2-1)
Date: Saturday, Sept. 24, 2022
Time: 10:15 p.m. ET
Venue: Lavell Edwards Stadium — Provo, UT
Coverage: ESPN2

Week 4 of the 2022 NCAA college football season includes a regional rivalry between the Wyoming Cowboys and Brigham Young Cougars.

This is Wyoming's first visit to Provo since 2010, and the Cowboys have dropped 8 straight in Provo vs. BYU. The 79th meeting between these two rivals is worth watching late Saturday night.

Wyoming vs BYU Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: WYOM: (+1000) | BYU: (-2100)
Spread: WYOM: +21.5 (-110) | BYU: -21.5 (-110)
Total: 49.5 — Over: (-114) | Under: (-106)

BYU enters this contest as a big -21.5 point favorite on the spread and is better than a 20/1 favorite on the moneyline. This Saturday night late kickoff also features a below average total of 49.5 points.

Wyoming vs BYU Prediction & Pick

Wyoming enters with a pair of home underdog wins under their hat, including last Friday's 17-14 win over 16-point favorite Air Force. The Cowboys also have a 40-37 OT win over high-scoring Tulsa. The Cowboys have over-achieved, and 9th year coach Craig Bohl and his staff have gotten the most out of the team with better game planning and play calls.

But BYU is now the Cowboys toughest opponent, and the Cougars are coming off a frustrating loss to Oregon in Eugene this past week, 41-20. BYU was missing four starters including a pair of top receivers, so monitor the injury reports on game day. Cougars star QB Jaren Hall still passed for 305 yards and 2 TDs in defeat against Oregon, and he'll likely lite it up against the Cowboys defense as the Cowboys defensive line and secondary rate among the bottom in the Mountain West. Tulsa QB Davis Brin passed for 460 yards and 3 TDs without an INT in 50 attempts against Wyoming.

BYU did beat then top-10 Baylor two weeks ago in Provo, 26-20 in overtime without their two leading receivers, and the Cougars will handle the Cowboys Saturday.

Final Score Prediction: BYU: 37 | Wyoming: 13

Wyoming vs BYU Betting Trends

• Wyoming is 4-1 straight up (SU) in their last 5 games.
• Wyoming is 6-3 against the spread (ATS) in their last 9 games.
• BYU is 15-1 SU in their last 16 home games.
• The total has gone Over in 4 of BYU's last 5 games.

Wyoming vs BYU Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

After a poor start to the season against Illinois, Cowboys QB Andrew Peasley has looked like a completely different quarterback completing 68.7 percent of his passes for 562 yards and 3 touchdowns. The Cowboys will need to minimize mistakes and balance the attack while sustaining drives to stay competitive.

BYU has more playmakers, if healthy, along with top-level QB Jaren Hall and a better defense. Bet BYU if at least one of their wide receivers returns along with two defensive ends who remain questionable.

Bet: BYU -21.5 (-110)