Rams vs 49ers Expert Picks & Predictions for Week 4 NFL Monday Night Football Game

The 2022 NFL season is finally here and the Week 4 schedule is chock full of exciting showdowns. One of the most interesting matchups of the week is a Monday Night Football affair between two NFC West teams as the LA Rams pay a visit to the San Francisco 49ers.

The Rams are beginning to look like themselves, winning their second straight game in the form of a 20-12 victory against the Arizona Cardinals. At the same time, the 49ers hope to get back into the win column after offense was hard to come by in their 11-10 loss to the Denver Broncos.

Can the Rams beat their rivals for the first time in the regular season since December 2018? Or will the 49ers continue their winning ways in front of a packed crowd at Levi's Stadium?

Here's what projection models and experts across the industry have to say about the Rams vs 49ers Week 4 MNF matchup.

Rams vs 49ers Projections

ESPN FPI: Rams (59.8%)
numberFire: 49ers (64.5%)
FiveThirtyEight: 49ers (55%)
Betting Favorite: 49ers (-1.5)

Projected Winner: 49ers (3), Rams (1)

Rams vs 49ers Expert Picks

ESPN Experts: Rams (4), 49ers (2)
Sports Illustrated Experts: 49ers (4), Rams (1)
CBS Sports Experts: Rams (5), 49ers (3)

Expert Totals: Rams (10), 49ers (9)

The Rams might be the defending champions, but it's the 49ers who are favored by three of the four projections. Things do shift in Los Angeles' direction (albeit, slightly) as 52.6% of highlighted experts side with the road team.

As far as a Rams upset goes, their best projection comes in at 59.8% on ESPN. After all, they did beat the 49ers, 20-17, when they met in the 2021-22 NFC Championship Game.

Regardless of who's being favored here, division rivalries bring out the best in most teams. With the bright Monday night lights shining down on this NFC West battle, both the Rams and 49ers have solid cases to emerge as the victor.

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.