Packers vs 49ers Prediction, Odds & Betting Trends for NFL Preseason Week 1 Game on FanDuel Sportsbook (Aug 12)

Packers vs 49ers Prediction, Odds & Betting Trends for NFL Preseason Week 1 Game on FanDuel Sportsbook (Aug 12)


Packers vs 49ers Preseason Game Info

2022 NFL Preseason — Week 1 Game
Green Bay Packers (0-0) vs. San Francisco 49ers (0-0)
Date: Friday, August 12, 2022
Time: 8:30 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: NFL Network

Week 1 of the 2022 NFL preseason includes a matchup between the Green Bay Packers and San Francisco 49ers in a rematch from last season's Division Round. It's another year where expectations are high for the Packers, who'll likely be using this game to audition wide receivers as they attempt to replace Davante Adams' production.

Meanwhile, the 49ers are looking to begin a new era with Trey Lance as their starting quarterback. Head coach Kyle Shanahan already confirmed that the former 2021 third overall pick will see playing time against the Packers and he must make the most of that opportunity.

Packers vs 49ers Odds & Spread

All NFL preseason betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: GB: (+120) | SF: (-140)
Spread: GB: +2.5 (-105) | SF: -2.5 (-115)
Total: 33.5 — Over: (-110) | Under: (-110)

The 49ers enter this preseason matchup being slightly favored at -140 on the moneyline while also being the 2.5-point spread favorites. This 8:30 p.m. ET clash also features a total set at 33.5 points. 

Packers vs 49ers Prediction & Pick

The Packers are rolling with Jordan Love as their starting quarterback at Levi's Stadium. The former 2020 26th overall pick hasn't looked good at all during his limited playing time and it's tough to imagine him having too much success against San Francisco's well-coached defense.

As mentioned before, Shanahan has already confirmed that Lance and some of the other 49ers starters will play on Friday. Even though Lance has had some rough moments at training camp, the talent is still there to be special and he can solidify San Francisco's trust in him with a strong performance against the Packers.

Final Score Prediction: 49ers: 20 | Packers: 13

Packers vs 49ers Betting Trends

- Green Bay is 1-5 against the spread (ATS) in its last six games played in August.
- San Francisco is 7-1 ATS in its last eight games against NFC teams.
- The total has hit the over in seven of Green Bay's last 10 road games against San Francisco.
- The total has hit the under in seven of San Francisco's last eight games.

Packers vs 49ers Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

Lance and the 49ers have more to prove on Friday, while the Packers usually keep things more conservative in the preseason. There isn't too much value to be had with an outright win by San Francisco, hence why I recommend taking the 49ers winning by one to 13 points.

Bet: 49ers Win Margin — 1-13 Points (+145)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.