Colts vs Broncos Prediction, Odds & Betting Trends for NFL Week 5 Thursday Night Football on FanDuel Sportsbook

Colts vs Broncos Week 5 Game Info

2022 NFL Regular Season Game
Indianapolis Colts (1-2-1, 0-1-1 Away) vs. Denver Broncos (2-2, 2-0 Home)
Date: Thursday, Oct. 6, 2022
Time: 8:15 p.m. ET
Venue: Empower Field at Mile High — Denver, CO
Coverage: Prime Video

Week 5 of the 2022 NFL season includes a showdown between the Indianapolis Colts and Denver Broncos. The Colts' division struggles continued over the weekend, picking up a 24-17 loss to the Tennessee Titans in a game that saw Indianapolis cough up the ball three times.

Meanwhile, the Broncos also come off a defeat, losing 32-23 to the rival Las Vegas Raiders. Denver couldn't make much happen when the ball was in its hands, being in possession for just 41.9% of the game while also going 3-of-11 on third-down conversions.

Colts vs Broncos Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (+146) | DEN: (-174)
Spread: IND: +3 (-104) | DEN: -3 (-116)
Total: 43.5 —Over: (-106) | Under: (-114)

The Broncos enter this contest as the home favorite on the moneyline and spread on FanDuel Sportsbook's odds. This 8:15 p.m. ET clash also features a total of 43.5, which is among the lowest of the projected Week 5 totals.

Colts vs Broncos Prediction & Pick

The Colts and Broncos have both struggled to find success to begin the 2022 NFL season. Having said that, Indianapolis has looked the worst of the two sides, averaging an NFL-worst 14.3 points per game. Now, things could get worse if No. 1 running back Jonathan Taylor can't suit up on Thursday.

The Broncos will likely be without RB Javonte Williams as well, but I do trust their passing game over the Colts. Matt Ryan just doesn't have enough chemistry with Indianapolis' pass-catchers yet, while Denver has a few talented ballhawks in its secondary.

This game likely won't be pretty (given what both teams have shown thus far), but I do expect the Broncos to emerge as the victors.

Final Score Prediction: Broncos: 23 | Colts: 17

Colts vs Broncos Betting Trends

- Indianapolis is 7-3 against the spread (ATS) in its last 10 games against Denver.
- Denver is 11-4 straight up in its last 15 games played on Thursday.
- The total has hit the under in each of Indianapolis' last eight games against the AFC.
- The total has hit the under in six of Denver's last eight home games.

Colts vs Broncos Best Bet

Neither offense is amazing here, which has me leaning towards a low-scoring affair. The Colts and Broncos combine for just 30.8 PPG thus far and while both offenses have struggled, their defenses have shown flashes of promise. In other words, backing the total finishing under 43.5 points is a good call here.

Bet: Under 43.5 Points (-114)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.