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Rams vs 49ers Prediction, Odds & Betting Trends for NFL Week 4 Monday Night Football on FanDuel Sportsbook

Larry Rupp
Los Angeles Rams vs San Francisco 49ers prediction, odds and betting trends for NFL Week 4 Monday Night Football game.
Los Angeles Rams vs San Francisco 49ers prediction, odds and betting trends for NFL Week 4 Monday Night Football game. / AP Photos/Mark J. Terrill
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Rams vs 49ers Week 4 Game Info

2022 NFL Regular Season — Week 4 Monday Night Football
Los Angeles Rams (2-1, 1-0 Away) vs. San Francisco 49ers (1-2, 1-0 Home)
Date: Monday, October 3, 2022
Time: 8:15 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: ESPN

A pair of NFC West rivals meet head-to-head in Week 4 as the San Francisco 49ers host the Los Angeles Rams on Monday Night Football. The Rams have won back-to-back games since a Week 1 loss to the Buffalo Bills and continue to lean on wide receiver Cooper Kupp (NFL-high 28 receptions).

Meanwhile, the 49ers have fallen to 1-2 after losing Jimmy Garoppolo's first start of the season. He completed 18 of his 29 pass attempts for 211 passing yards, 1 touchdown and 1 interception. Two scoring drives were not enough to get by the Denver Broncos in a tough 11-10 road defeat.

Rams vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LAR: (+108) | SF: (-126)
Spread: LAR: +2.5 (-110) | SF: -2.5 (-110)
Total: 42.5 — Over: (-110) | Under: (-110)

San Francisco enters this contest as a slight home favorite on the moneyline and the spread. This Monday night clash also features one of the lower projected totals (42.5) on the NFL Week 4 slate.

Rams vs 49ers Prediction & Pick

These teams met three times last season as the 49ers swept the regular season series before the Rams earned the victory in the NFC Championship game. It was LA's first win against San Francisco since 2018 and broke a six-game losing streak in the rivalry. Momentum is back on their side now.

There's a lot to like about the Rams' chances of pulling off an upset here. The 49ers may be without All-Pro tackle Trent Williams on Monday. Not only does that hurt San Francisco's rushing attack, but it also leaves Jimmy G vulnerable to a defensive line that has already posted 7.0 sacks on the season.

Final Score Prediction: Rams: 27 | 49ers: 17

Rams vs 49ers Betting Trends

- The Rams are 6-0 straight up in their last six away games.
- The total has hit the under in four of the Rams' last five games.
- San Francisco is 5-0 against the spread (ATS) in its last five home games.
- The total has hit the under in four of San Francisco's last five games against the Rams.

Rams vs 49ers Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

The first three weeks of the 2022 NFL season have shown that plenty of upsets are going to go down before the playoffs roll around. Backing a Rams team that is 4-1 against the spread (ATS) in its last five Monday Night Football games and 6-0 straight up in its last six away games is a great upset pick.

LA's underwhelming offensive line killed them in Week 1, but it has looked much improved over the last two weeks. Keeping quarterback Matthew Stafford upright will be the key to victory. This is the exact type of win the Rams need to cement themselves as the favorites to win the NFC West.

Bet: Rams Moneyline (+108)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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