Jaguars vs Chiefs Prediction, Odds & Best Bets for Week 10 (Chiefs Pull Away in Second Half Against Jaguars)

Jaguars vs Chiefs Week 10 Game Info

2022 NFL Regular Season — Week 10
Jacksonville Jaguars (3-6, 1-3 Away) vs. Kansas City Chiefs (6-2, 3-1 Home)
Date: Sunday, Nov. 13, 2022
Time: 1:00 p.m. ET
Venue: GEHA Field at Arrowhead Stadium — Kansas City, MO
Coverage: CBS

The Kansas City Chiefs will look to defend home field advantage when they host the Jacksonville Jaguars in Week 10 NFL action. The Jaguars snapped a five-game losing streak in Week 9 with a 27-20 win over the Las Vegas Raiders. Running back Travis Etienne tallied 126 yards and 2 touchdowns.

Meanwhile, the Chiefs needed to mount a second-half comeback to take down the Tennessee Titans by a score of 20-17 in overtime. Quarterback Patrick Mahomes carried the offense on his back with 446 passing yards on a career-high 68 pass attempts, 63 rushing yards and 2 total touchdowns.

Jaguars vs Chiefs Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: JAC: (+340) | KC: (-430)
Spread: JAC: +9.5 (-110) | KC: -9.5 (-110)
Total: 50.5 — Over: (-110) | Under: (-110)

The Chiefs enter this contest as a heavy home favorite on the moneyline and the spread. This 1 p.m. ET clash also features one of the higher totals on the Week 10 slate at 50.5 points.

Jaguars vs Chiefs Prediction & Pick

This is a team Mahomes has demolished so far in his career. The former Texas Tech QB is 2-0 against the Jaguars with 691 passing yards and 4 total touchdowns (2 interceptions). Overall, Kansas City has won five straight games against Jacksonville and four of those victories have come by double-digits.

The Chiefs are in need of a "get right" win after barely escaping Arrowhead with a win last weekend. With the Bills suffering their second loss of the season, the No. 1 seed in still up for grabs. Look for Kansas City to pick apart a Jacksonville defense that allows 24.4 points per away game (No. 23 in NFL).

Final Score Prediction: Jaguars: 17 | Chiefs: 31

Jaguars vs Chiefs Betting Trends

- Jacksonville is 1-5 against the spread (ATS) in its last six games.
- The total has hit the over in each of Jacksonville's last six away games.
- Kansas City is 5-0 straight up in its last five games against Jacksonville.
- The total has hit the over in 11 of Kansas City's last 16 games.

Jaguars vs Chiefs Best Bet

Jacksonville simply doesn't have the offensive talent to keep up in this game. Despite averaging the eighth-most yards per game in the NFL (367.4), the Jaguars are only scoring 22.1 points per game (No. 18 in NFL). That because they own a weak red zone scoring percentage of 52.9% (No. 21 in NFL).

The key for Kansas City here will be keeping quarterback Trevor Lawrence uncomfortable. If the Chiefs can do that, they can pull away in the second half. Overall, Jacksonville is a dismal 1-5 against the spread (ATS) over its last six games in 2022 and 1-5 ATS in its last six games against Kansas City.

Bet: Kansas City Chiefs -9.5 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.