Commanders vs 49ers Prediction, Odds & Best Bets for Week 16 (San Francisco Builds Another Early Lead)

Larry Rupp
Washington Commanders vs San Francisco 49ers prediction, odds and best bets for NFL Week 16 game.
Washington Commanders vs San Francisco 49ers prediction, odds and best bets for NFL Week 16 game. / AP Photos/Stephen Brashear
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Commanders vs 49ers Week 16 Game Info

2022 NFL Regular Season — Week 16
Washington Commanders (7-6-1, 4-2-1 Away) vs. San Francisco 49ers (10-4, 6-1 Home)
Date: Saturday, Dec. 24, 2022
Time: 4:05 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: CBS

The Washington Commanders will aim to make up ground in the NFC Wild Card race when they visit the San Francisco 49ers in Week 16 NFL action. Washington fell short in a 20-12 loss to the New York Giants on Sunday. The Commanders failed to convert a goal-to-go situation at the end of the game.

Meanwhile, San Francisco picked apart the Seattle Seahawks in a 21-13 Week 15 win and clinched the NFC West title as a result. Rookie quarterback Brock Purdy put together yet another efficient outing. He completed 17 of his 26 pass attempts for 217 yards and 2 touchdowns (0 interceptions).

Commanders vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: WAS: (+275) | SF: (-340)
Spread: WAS: +7.5 (-114) | SF: -7.5 (-106)
Total: 39.5 — Over: (-110) | Under: (-110)

The 49ers enter this contest as clear home favorites on the moneyline and spread on FanDuel Sportsbook's odds. This 4:05 p.m. ET clash also features one of the lower totals on the Week 16 slate at 39.5 points.

Commanders vs 49ers Prediction & Pick

The Commanders had an opportunity to put themselves in position to earn a playoff spot, but they struggled to create any offensive success. That has been happening all year long, too. Washington ranks 20th in yards (335.5), 25th in points (18.9) and 26th in third down conversions (4.6) per game.

That is not what head coach Ron Rivera wants to see with the 49ers' defense balling out as of late. San Francisco has posted the best total DVOA rating in the NFL and has allowed an average of just 12.3 points over its last three games. The 49ers also rank tied for seventh with 39.0 sacks in 2022.

San Francisco is 10-1 straight up in its last 11 home games, so I trust the 49ers to get the job done.

Final Score Prediction: Commanders: 17 | 49ers: 27

Commanders vs 49ers Betting Trends

- Washington is 6-2-1 against the spread (ATS) in its last nine games.
- The total has hit the under in nine of Washington's last 12 games.
- San Francisco is 13-5 straight up in its last 18 games against Washington.
- The total has hit the under in five of San Francisco's last six games against Washington.

Commanders vs 49ers Best Bet

The 49ers are riding a seven-game winning streak that has been held up by a defense that dominates early. San Francisco is allowing only 7.1 first half points per game this season (No. 1 in NFL). That is not good news for a Washington offense averaging just 8.6 first half points per game (No. 26 in NFL).

It is good news for anyone looking to back the 49ers on the first half spread, though. San Francisco has led by at least a touchdown at the break in each of its last five games. Overall, it is 10-4 against the spread (ATS) in the first half this year, while Washington is a dismal 5-9 ATS in the first half.

Bet: San Francisco 49ers First Half -3.5 (-115)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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