Clemson vs Notre Dame Prediction, Odds & Betting Trends for College Football Week 10 Game on FanDuel Sportsbook

Clemson vs Notre Dame Week 10 Game Info

2022 NCAA College Football Game
No. 4 Clemson Tigers (8-0) vs. Notre Dame Fighting Irish (5-3)
Date: Saturday, Nov. 5, 2022
Time: 7:30 p.m. ET
Venue: Notre Dame Stadium — Notre Dame, IN
Coverage: NBC/Peacock

Week 10 of the 2022 NCAA college football season includes an exciting showdown between the No. 4 Clemson Tigers and the Notre Dame Fighting Irish. Clemson took care of business against Syracuse in a 27-21 win in Week 8 before going on bye. Running back Will Shipley tallied 189 total yards and scored 2 touchdowns.

Meanwhile, Notre Dame got back on track with its own win over Syracuse in Week 9. Running backs Audric Estime and Logan Diggs combined for 208 yards and 3 touchdowns on the ground in the 41-24 victory. On defense, Marist Liufau and Brandon Joseph each nabbed an interception for the Fighting Irish.

Clemson vs Notre Dame Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: CLEM: (-172) | NOTRE: (+142)
Spread: CLEM: -3.5 (-115) | NOTRE: +3.5 (-105)
Total: 43.5 — Over: (-110) | Under: (-110)

Clemson enters this contest as a small favorite on the moneyline and the spread. This Saturday night clash also features a total of 43.5 points, which is below average compared to this week's college football projected totals.

Clemson vs Notre Dame Prediction & Pick

A slow start by Notre Dame has taken them out of the College Football Playoff conversation, but they can still make headlines with a home upset over Clemson. Head coach Marcus Freeman will have his players revved up for a matchup everyone had circled on their calendars coming into the season.

Keep in mind the Fighting Irish have won a ridiculous 26 straight regular season games against ACC opponents. They also demolished the Orange on the road, while the Tigers escaped at home against that same opponent. Notre Dame needs a win for bowl eligibility and they'll find a way to earn it here, spoiling Clemson's undefeated season.

Final Score Prediction: Clemson: 21 | Notre Dame: 24

Clemson vs Notre Dame Betting Trends

- Clemson is 5-0 straight up in its last five away games.
- The total has hit the over in four of Clemson's last six games.
- Notre Dame is 6-0 against the spread (ATS) in its last six games against the ACC.
- The total has hit the over in four of Notre Dame's last six games as an underdog.

Clemson vs Notre Dame Best Bet

It's risky to back an outright loss for the No. 4 ranked team in the country, so shifting gears to the spread here is a logical move. Notre Dame is 6-0 against the spread (ATS) in its last six games against an ACC opponent, while Clemson is only 2-8 ATS in its last 10 games against a non-conference foe.

The Fighting Irish have not lost a game by more than a field goal since Week 2. They are starting to click on offense, too, averaging a reliable 34.4 points over their last five games. Look for this one to stay close until the winning squad nails a late field goal.

Bet: Notre Dame +3.5 (-105)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.