Browns vs Bills Prediction, Odds & Best Bet for Week 11 (Bills Bounce Back by Blowing Out Browns)

Devon Platana
Cleveland Browns vs Buffalo Bills prediction, odds and betting trends for NFL Week 11.
Cleveland Browns vs Buffalo Bills prediction, odds and betting trends for NFL Week 11. / (AP Photo/Adrian Kraus)
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Browns vs Bills Week 11 Game Info

2022 NFL Regular Season Game
Cleveland Browns (3-6, 1-3 Away) vs. Buffalo Bills (6-3, 3-1 Home)
Date: Sunday, Nov. 20, 2022
Time: 1 p.m. ET
Venue: Ford Field — Detroit, MI
Coverage: CBS

Week 11 of the 2022 NFL season includes an AFC tilt between the Cleveland Browns and Buffalo Bills. Playing on the road has been tough for the Browns, who haven't won an away game since Week 1. They've also lost five of their last six outings overall, including last week's 39-17 defeat to the Miami Dolphins.

The Bills enter this game in uncharted territory, having lost back-to-back games for the first time this season. Their latest defeat was a 33-30 overtime loss to the Minnesota Vikings on Sunday — a game where Buffalo recorded an uncharacteristic four turnovers (two fumbles, two interceptions).

Browns vs Bills Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: CLE: (+290) | BUF: (-360)
Spread: CLE: +7.5 (-105) | BUF: -7.5 (-115)
Total: 49.5 —Over: (-118) | Under: (-104)

Updated (Sunday, Nov. 20, 12:20 p.m. ET): The odds improved in Cleveland's favor following a move to the neutral site of Ford Field in Detroit, MI. Cleveland is now just a 7.5-point underdog (compared to 8.5 points) and the over/under jumped from 43.5 to 49.5 points. The lack of weather should have both offenses playing in top form.

The Bills enter this contest as clear favorites on the moneyline and spread on FanDuel Sportsbook's updated odds. This AFC clash also features an over/under of 43.5, which is average compared to the Week 11 totals. 

Browns vs Bills Prediction & Pick

The Bills haven't looked like themselves lately, but that should change this week. The Browns are absolutely terrible this season and everyone knows it, including the coaching staff. Cleveland has also lost each of its last three road games by a combined score of 85-57, being held to 20 or fewer points in each of those outings.

The Browns are also a bottom-10 team against both the pass and run this season, giving up 349.1 total yards per game. That's a recipe for disaster against the Bills, who can, essentially, score at will through the air or on the ground depending on the situation.

It's also worth noting that the Browns haven't beaten the Bills on the road since October 2009. The former has lost each of its last three trips to Highmark Stadium by an average of 14.3 points, showcasing how tough it is to play against Buffalo in front of Bills Mafia.

The Bills are much better than they've looked over their last two games. With how terrible the Browns have been, look for the Bills to get back on track with another dominant victory.

Final Score Prediction: Bills: 35 | Browns: 17

Browns vs Bills Betting Trends

- Cleveland is 1-7 straight up in its last eight road games.
- Buffalo is 4-1-1 against the spread (ATS) in its last six games against Cleveland.
- The total has hit the over in six of Cleveland's last nine games.
- The total has hit the under in five of Buffalo's last seven games against Cleveland.

Browns vs Bills Best Bet

As far as best bets go, I'm going with the Bills as 8.5-point favorites here. Not only have the Bills' home wins this season come by an average of 26.3 points, but they've also covered the spread in four of their last six games against the Browns.

Couple that with the Browns being a terrible road team and failing to cover the spread in four of their last six games, I've got the Bills winning this one by at least nine points.

Bet: Bills -8.5 (-105)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.

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