Bills vs Lions Opening Odds, Betting Lines & Prediction for Week 12 Thanksgiving Game on FanDuel Sportsbook

Larry Rupp
Bills vs Lions NFL opening odds, lines and predictions for Week 12 game on FanDuel Sportsbook.
Bills vs Lions NFL opening odds, lines and predictions for Week 12 game on FanDuel Sportsbook. / AP Photos/Jeffrey T. Barnes

Week 11 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 12, giving us an early preview of the upcoming slate.

Week 12 includes a Thanksgiving cross conference battle between the Buffalo Bills and Detroit Lions.

Bills vs Lions Odds & Lines Week 12

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF: (-500) | DET: (+385)
Spread: BUF: -10 (-110) | DET: +10 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

The Lions are projected as heavy home underdogs in Week 12. Buffalo is an early -500 moneyline favorite and favored by 10 points on the spread.

Bills vs Lions Prediction Week 12

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
Bills: 83.9% to win
Lions: 15.9% to win

The Lions have ripped off back-to-back wins heading into Week 11, while the Bills have lost back-to-back games as favorites. None of that matters, though. Detroit ranks 24th in pass defense DVOA rating and ranks 27th in run defense DVOA rating. Meanwhile, Buffalo boasts the fifth-best total offense DVOA rating. Wide receiver Stefon Diggs and running back Devin Singletary should tear this defense apart. Take the Bills -10.

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.