Bills vs Bears Prediction, Odds & Best Bet for Week 16 (Josh Allen & Co. Don't Break a Sweat in Trip to Windy City)

Bills vs Bears Week 16 Game Info

2022 NFL Regular Season Game
Buffalo Bills (11-3, 5-2 Away) vs. Chicago Bears (3-11, 2-5 Home)
Date: Saturday, Dec. 24, 2022
Time: 1 p.m. ET
Venue: Soldier Field — Chicago, IL
Coverage: CBS

Week 16 of the 2022 NFL season features a slate of Christmas Eve matchups, including a showdown between the Buffalo Bills and Chicago Bears.

After a 32-29 win over the Miami Dolphins, it's clear that the Bills are one of the NFL's hottest teams, having won five straight games ahead of this matchup. On the other hand, the Bears picked up their seventh straight loss over the weekend, losing 25-20 to the Philadelphia Eagles at Soldier Field.

Do the Bills have what it takes to extend their streak to six games? Or will the Bears finally figure out how to pick up their first home win since Week 3?

Bills vs Bears Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF (-405) | CHI: (+320)
Spread: BUF: -8.5 (-114) | CHI: +8.5 (-106)
Total: 41.5 —Over: (-104) | Under: (-118)

The Bills enter this contest as clear road favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Christmas Eve matchup also features an over/under of 41.5, which is right in the middle of the Week 16 totals. 

Bills vs Bears Prediction & Pick

The Bills have been fantastic on both sides of the ball this season, scoring the fourth-most points (27.5 PPG) while allowing the second fewest (17.9 PPG). They've also been beating teams by just over a touchdown during their win streak, averaging a plus-7.2 scoring margin during that time.

Meanwhile, the Bears have lost five consecutive home games, giving up an average of 29.8 points in the last four. Chicago has also surrendered the fourth-most total yards (414.7) over its last three games and owns the worst third-down defense this season, further indicating that the Bears likely won't be able to stop the Bills' non-stop attack.

This game is a mismatch and there's no reason to believe that the Bears can pull off the upset. Back the Bills to continue rolling along down the stretch.

Final Score Prediction: Bills: 31 | Bears: 10

Bills vs Bears Betting Trends

- Buffalo is 5-0 straight up in its last five games.
- Chicago is 1-4 against the spread (ATS) in its last five games.
- The total has hit the under in each of Buffalo's last seven road games.
- The total has hit the over in four of Chicago's last five games against the AFC East.

Bills vs Bears Best Bet

As far as the best bet goes, I'm expecting this game to finish with the under on the 41.5-point total. Despite the Bills' high-flying offense, they've finished with the under in nine of their last 12 games, as well as seven straight on the road.

Sure, the over has been hit in seven of the Bears' last eight outings, but I don't see them getting much offense to help in that regard this week. Buffalo's defense will shut Chicago down without much difficulty, playing a big role in the two sides combining for under 41.5 points.

Bet: Under 41.5 Points (-118)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.