49ers vs Panthers Prediction, Odds & Betting Trends for NFL Week 5 Game on FanDuel Sportsbook

49ers vs Panthers Week 5 Game Info

2022 NFL Regular Season Game
San Francisco 49ers (1-2, 0-2 Away) vs. Carolina Panthers (1-3, 1-2 Home)
Date: Sunday, Oct. 9, 2022
Time: 4:05 p.m. ET
Venue: Bank of America Stadium — Charlotte, NC
Coverage: CBS

Week 5 of the 2022 NFL season includes a showdown between the San Francisco 49ers and Carolina Panthers. At the time of writing, the 49ers have yet to play their Week 4 matchup against the Los Angeles Rams, leaving time to tell if San Francisco can bounce back from the previous week's loss or if their losing streak grows to two.

Meanwhile, the Panthers continued their early season struggles in the form of a 26-16 loss to the Arizona Cardinals on Sunday. Ball security was one of Carolina's many issues in the loss, highlighted by quarterback Baker Mayfield's pair of interceptions on the day.

49ers vs Panthers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-280) | CAR: (+230)
Spread: SF: -6.5 (-110) | CAR: +6.5 (-110)
Total: 39.5 —Over: (-110) | Under: (-110)

Updated (Sunday, Oct. 9, 9:50 a.m. EST): The 49ers enter this contest as the road favorite on the moneyline and spread on FanDuel Sportsbook's updated odds, which have tilted more in their favor as the week has progressed. This 4:05 p.m. ET clash also features a total of 39.5, which is the lowest total on the Sunday slate.

49ers vs Panthers Prediction & Pick

Both teams may have had their struggles so far, but my money is on the 49ers here. San Francisco has had issues scoring the ball, but its defense allowing a league-low 12.3 points per game has more than made up for it. Meanwhile, Carolina has averaged the ninth-fewest points since Week 2 (18.0) — not exactly encouraging.

The 49ers are a run-heavy team and the fact that the Panthers surrender 134 rushing yards per game (eighth-most) has San Francisco licking its lips. Once the 49ers take the lead, they have the talent to run out the clock, making this game one that the Panthers-favoring bettors might want to avoid.

Final Score Prediction: 49ers: 24 | Panthers: 13

49ers vs Panthers Betting Trends

- San Francisco is 10-5 straight up in its last 15 games.
- Carolina is 7-3 against the spread (ATS) in its last 10 games against San Francisco.
- The total has hit the under in each of San Francisco's last five games against the NFC.
- The total has hit the under in five of Carolina's last seven games.

49ers vs Panthers Best Bet

Fans expecting a lot of points on the board will be disappointed here. Neither team has shown much offensive flair so far this season, finishing with fewer than 20 points scored more often than not. Although I do expect the 49ers to score the ball a few times this weekend, the Panthers' offensive struggles will likely result in this game going below 39.5 points.

Bet: Under 39.5 Points (-110)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.