Guardians vs Yankees Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 5:13 p.m.

MLB action on Tuesday includes the Cleveland Guardians taking on the New York Yankees.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Yankees Game Info

• Cleveland Guardians (13-9) vs. New York Yankees (14-9)
• Date: Tuesday, April 22, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and YES

Guardians vs Yankees Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-112) | NYY: (-104)
• Spread: CLE: +1.5 (-192) | NYY: -1.5 (+158)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Guardians vs Yankees Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 1-2, 5.85 ERA vs Will Warren (Yankees) - 1-0, 5.17 ERA

The probable pitchers are Tanner Bibee (1-2) for the Guardians and Will Warren (1-0) for the Yankees. Bibee and his team are 2-2-0 ATS this season when he starts. Bibee's team is 1-1 this season when he starts and they're favored on the moneyline. When Warren starts, the Yankees have gone 2-2-0 against the spread. The Yankees were the moneyline underdog for one Warren start this season -- they lost.

Guardians vs Yankees Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.8%)

Guardians vs Yankees Moneyline

• Cleveland is a -112 favorite on the moneyline, while New York is a -104 underdog on the road.

Guardians vs Yankees Spread

• The Yankees are 1.5-run favorites against the spread for this matchup with the Guardians. The Yankees are +158 to cover, while the Guardians are -192 to cover as a 1.5-run underdog on the runline.

Guardians vs Yankees Over/Under

• A combined run total of 8.5 has been set for Guardians-Yankees on April 22, with the over at -118 and the under at -104.

Bet on Cleveland Guardians vs. New York Yankees on FanDuel today!

Guardians vs Yankees Betting Trends

• The Guardians have come away with seven wins in the nine contests they have been listed as the favorites in this season.
• Cleveland has a record of 7-2 in contests when oddsmakers favor them by -112 or more on the moneyline.
• The Guardians and their opponents have gone over the total this season in 12 of their 22 opportunities.
• In 22 games with a line this season, the Guardians have a mark of 10-12-0 against the spread.
• The Yankees have been the underdog on the moneyline a total of three times this season, and they've lost each of those games.
• New York has played in three games as a moneyline underdog with odds of -104 or longer without a win.
• The Yankees have played in 23 games with an over/under set, and have combined with opponents to go over the total 12 times (12-9-2).
• The Yankees have put together an 11-12-0 record against the spread this season (covering 47.8% of the time).

Guardians Player Leaders

• Steven Kwan has an OPS of .902, fueled by an OBP of .396 to go with a slugging percentage of .506. He has a .333 batting average, as well.
• Among qualifying hitters in baseball, his batting average ranks 11th, his on-base percentage ranks 21st, and he is 33rd in slugging.
• Kwan has picked up at least one hit in five straight games. In his last five games he is hitting .400 with two doubles, a home run, three walks and three RBI.
• Jose Ramirez is batting .276 with four doubles, five home runs and eight walks. He's slugging .526 with an on-base percentage of .337.
• Among qualifying batters, he ranks 59th in batting average, 76th in on-base percentage and 26th in slugging percentage.
• Ramirez brings a four-game streak with at least one hit into this matchup. During his last five outings he is hitting .300 with a double, a home run, two walks and five RBI.
• Kyle Manzardo leads Cleveland in total hits (15) this season, and 10 of those have gone for extra bases.
• Manzardo enters this game with five games in a row with at least one hit. During his last five outings he is hitting .333 with a double, three home runs, two walks and six RBI.
• Gabriel Arias has four home runs, 10 RBI and a batting average of .275 this season.
• Arias heads into this game on a three-game hitting streak. During his last five outings he is hitting .250 with two doubles, a home run, a walk and three RBI.

Yankees Player Leaders

• Aaron Judge has totaled 33 hits with a .490 on-base percentage and a .698 slugging percentage, all club-highs for the Yankees. He's batting .384.
• Including all qualified hitters in MLB, his batting average places him first, his on-base percentage is first, and he is first in slugging.
• Judge brings a three-game hitting streak into this matchup. During his last five outings he is batting .300 with a double, three walks and four RBI.
• Ben Rice is batting .288 with three doubles, a triple, five home runs and 10 walks. He's slugging .591 with an on-base percentage of .397.
• Including all qualifying hitters, his batting average puts him 41st, his on-base percentage ranks 20th, and he is 13th in slugging.
• Anthony Volpe is hitting .217 with five doubles, four home runs and 11 walks.
• Paul Goldschmidt is batting .372 with five doubles, a home run and seven walks.

Guardians vs Yankees Head to Head

• 4/21/2025: 6-4 CLE (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/19/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 10/18/2024: 8-6 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 10/17/2024: 7-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 10/15/2024: 6-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 10/14/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/22/2024: 6-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/21/2024: 8-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/20/2024: 9-5 CLE (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/14/2024: 8-7 CLE (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!